2

votes

Any benefit to supplementing with Vit K2 in the MK-7 form?

Answered on September 12, 2014
Created October 22, 2011 at 4:20 PM

I accidentally bought a k2 supplement in the MK-7 form instead of MK-4. Would you bother taking this? Thanks a lot!

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on September 07, 2013
at 01:28 AM

Jay K3 is being studied in several oncologic trials as we speak. It is being used by humans just not wide scaled because we are studying it.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 24, 2011
at 06:31 PM

You BOTH wrote it is used for cancer PREVENTION. That is DIFFERENT from cancer TREATMENT. Use of vitamin K3 in healthy people to prevent cancer is untested and unwise.

77877f762c40637911396daa19b53094

(78407)

on October 23, 2011
at 03:37 PM

Yes, its chemo, when did I say it isn't ? Anyway, the fact that K3 has anticancer role probably translates to other K vitamins in some level. K3 is provitamin K2, so at least part of it is used to make it in the body. K3 is used extensively with animals.

77877f762c40637911396daa19b53094

(78407)

on October 23, 2011
at 03:26 PM

Yes, MK-7 is found A LOT in the fermented diet of any kind. Its even produced by microbiota, if you have them :)

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 02:30 AM

Not all true. Mk-7 is in our diets in cheese. Also, there's no evidence that complexes are better.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 01:02 AM

Maj, similar comment for you. IV vit C and K3 are used because they are OXIDANTS, meaning they kill shit, like cancer cells. It's chemo.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 01:00 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (I think it's just used to treat, but not prevent, some cancers). It is used in some commercial animal feeds. Not stuff i would mess around with

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 12:59 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (rally just for chemotherapy (i.e., to kill cancer cells not to prevent their formation). It is used in some commercial animal feeds. Not stuff i would mess around with.

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on October 22, 2011
at 09:00 PM

K3 is the cancer preventer in the k vitamins. K2 plays a role too. Plus one

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on October 22, 2011
at 08:59 PM

Plus one.......all true

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on October 22, 2011
at 08:59 PM

Has a long half life .....than mk 4. For boenes and heart i love mk 4

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:33 PM

See some info here: http://www.naturemedclinic.com/intravenous-vitamin-c.php

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:31 PM

It looks like K is very important for cancer prevention. Apatone, combination of synthetic K3 and vitamin C megadose looks promicing for prostate cancer and Riordan clinic is using the same protocol for all cancers with big success.

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:08 PM

Here is from book: http://books.google.com/books?id=-xn_5iXneu0C&lpg=PA11&ots=hB7wrYz9NJ&dq=menaquinone-7%20benefits&pg=PA11#v=onepage&q=menaquinone-7%20benefits&f=false

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:04 PM

http://www.clotinase.com/research/Effect-of-vitamin-K2-(menaquinone-7)-in-fermented-soybean.pdf http://www.nextbio.com/b/search/individualtrial.nb?id=NCT00732576

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:03 PM

Ongoing: http://clinicaltrials.gov/ct2/show/NCT00642551 Just search god damn it.

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:03 PM

Or: http://www.ncbi.nlm.nih.gov/pubmed/15630245

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 06:54 PM

Not true. For instance: http://www.ncbi.nlm.nih.gov/pubmed/17158229. MK-7 is also produced by bacteria and part of beneficial effects of those microbiota must be due to it.

E5c7f14800c5992831f5c70fa746dc5c

(12867)

on October 22, 2011
at 06:34 PM

mk-4 is the only one with proven benefits in clinical trials

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3 Answers

5
4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 22, 2011
at 07:25 PM

There's decent data for K1, and multiple forms of K2, including mk-7 and mk-4. The type of data supporting each is currently different, a testament to the infancy of the state of knowledge on this topic.

There's a randomized placebo controlled trial in humans showing, as a secondary endpoint, drastic reductions of cancer among otherwise D3 replete women (mean serum level 30ng/ml) who took 5mg of k1 (a big dose). There's also generally good safety date for k1.

K2 in the mk-7 form has good epidemiological data, though I suspect some of the benefits that K2 shows in these studies is really due to the benefits of eating dairy fat (but the researchers can't accept that so they attribute it to K2). Same phenomenon for CLA.

Mk-4 has decent animal data behind it and some short-term trials in people (but only at massive doses that, in my opinion, would be quite unwise to take for purposes of disease prevention).

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 12:59 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (rally just for chemotherapy (i.e., to kill cancer cells not to prevent their formation). It is used in some commercial animal feeds. Not stuff i would mess around with.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 01:02 AM

Maj, similar comment for you. IV vit C and K3 are used because they are OXIDANTS, meaning they kill shit, like cancer cells. It's chemo.

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on September 07, 2013
at 01:28 AM

Jay K3 is being studied in several oncologic trials as we speak. It is being used by humans just not wide scaled because we are studying it.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 01:00 AM

QUILT, that's plum wrong. K3, or menadione, is a synthetic analogue of vitamin K. As far as I know it's rarely used in humans (I think it's just used to treat, but not prevent, some cancers). It is used in some commercial animal feeds. Not stuff i would mess around with

77877f762c40637911396daa19b53094

(78407)

on October 23, 2011
at 03:37 PM

Yes, its chemo, when did I say it isn't ? Anyway, the fact that K3 has anticancer role probably translates to other K vitamins in some level. K3 is provitamin K2, so at least part of it is used to make it in the body. K3 is used extensively with animals.

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on October 22, 2011
at 09:00 PM

K3 is the cancer preventer in the k vitamins. K2 plays a role too. Plus one

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:33 PM

See some info here: http://www.naturemedclinic.com/intravenous-vitamin-c.php

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:31 PM

It looks like K is very important for cancer prevention. Apatone, combination of synthetic K3 and vitamin C megadose looks promicing for prostate cancer and Riordan clinic is using the same protocol for all cancers with big success.

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 24, 2011
at 06:31 PM

You BOTH wrote it is used for cancer PREVENTION. That is DIFFERENT from cancer TREATMENT. Use of vitamin K3 in healthy people to prevent cancer is untested and unwise.

5
77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 05:41 PM

Yes, it might even be the most powerful form. MK-7 is found in fermented foods and that is basically the one your bacteria make in intestines.

MK-7 has a profound ability at preventing osteoporosis, and even at reversing it and calcification. It is the main stuff in natto and also one of dominant forms in human serum.

Ideally you should aim for mix of all K vitamins. Fermented foods contain other MK forms (8,3, 9 etc..) with possible different roles in the body.

It looks like its very safe. This is interesting

Therefore, under the conditions of this experiment, the median lethal dose (LD50) of MK-7 after a single oral administration in mice was determined to be greater than the limit dose level of 2000???mg/kg body weight. The no observed adverse effect level (NOAEL) of MK-7, when administered orally to rats for 90 days, was considered to be equal to 10???mg/kg body weight/day, the highest dose tested, based on lack of toxicity during the 90-day study period

Read More: http://informahealthcare.com/doi/abs/10.3109/15376516.2011.568983

This striking lack of toxicities with orthomolecular compunds relative to pharmaceuticlas is the reason why Pauling created new medicine. Ofcourse, rat observations do not necessarily translate to humans, but since you can't test LD-50 on humans its reasonable alternative.

See this table for dietary reference.

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:08 PM

Here is from book: http://books.google.com/books?id=-xn_5iXneu0C&lpg=PA11&ots=hB7wrYz9NJ&dq=menaquinone-7%20benefits&pg=PA11#v=onepage&q=menaquinone-7%20benefits&f=false

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:03 PM

Or: http://www.ncbi.nlm.nih.gov/pubmed/15630245

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:04 PM

http://www.clotinase.com/research/Effect-of-vitamin-K2-(menaquinone-7)-in-fermented-soybean.pdf http://www.nextbio.com/b/search/individualtrial.nb?id=NCT00732576

E5c7f14800c5992831f5c70fa746dc5c

(12867)

on October 22, 2011
at 06:34 PM

mk-4 is the only one with proven benefits in clinical trials

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on October 22, 2011
at 08:59 PM

Has a long half life .....than mk 4. For boenes and heart i love mk 4

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 07:03 PM

Ongoing: http://clinicaltrials.gov/ct2/show/NCT00642551 Just search god damn it.

77877f762c40637911396daa19b53094

(78407)

on October 22, 2011
at 06:54 PM

Not true. For instance: http://www.ncbi.nlm.nih.gov/pubmed/17158229. MK-7 is also produced by bacteria and part of beneficial effects of those microbiota must be due to it.

4
5e36f73c3f95eb4ea13a009f4936449f

(8280)

on October 22, 2011
at 06:28 PM

My recollection is that the MK-4 K2 variant is fast acting and cleared from the system quickly, and MK-7 lasts longer in the blood. So it's definitely worth taking it if you've got it, although complex's of the K vitamins are better. The various K vitamins help out with osteoporosis, arterial calcification, cancers, etc. and the K2-MK7 variant is not really in our diets (unless you eat Natto a lot, not common in the US diet)

4781cf8ae1bfcb558dfb056af17bea94

(4359)

on October 23, 2011
at 02:30 AM

Not all true. Mk-7 is in our diets in cheese. Also, there's no evidence that complexes are better.

77877f762c40637911396daa19b53094

(78407)

on October 23, 2011
at 03:26 PM

Yes, MK-7 is found A LOT in the fermented diet of any kind. Its even produced by microbiota, if you have them :)

Ed71ab1c75c6a9bd217a599db0a3e117

(25467)

on October 22, 2011
at 08:59 PM

Plus one.......all true

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