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Sulfur supplementation for Glutathione production?

Answered on August 19, 2014
Created July 19, 2012 at 3:04 AM

Glutathione is known as the mother of all antioxidants and a super liver detoxifier.

In addition to folate and vitamin b6 and b12 sulfur is an important precursor.

You can supplement folate (especially as 5-methyl-folate NOT folic acid), b6 and b12 but what about sulfur? Many people do not eat nearly enough cruciferous vegetables that provide the highest amount of sulfur. Can you safely/effectively supplement sulfur? Have you done it?

I have never seen a sulfur supplement in capsules. Only in powdered form I would imagine it is pretty stinky.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:24 PM

Humans do not utilize inorganic sulfates in protein synthesis.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:23 PM

However, none of those non-amino acid sulfur sources can be used for glutathione synthesis.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:22 PM

Not all sulfurous compounds can be used to biosynthesize glutathione, in fact, only the sulfur-containing amino acids can.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:21 PM

Humans do not utilize inorganic sulfur for the synthesis of animo acids. Sulfur-containing amino acids must be consumed in amino acid form.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:20 PM

Inorganic sulfur/sulfites/sulfates do not get used in protein synthesis. MSM also does not get used in protein synthesis, as far as I've seen. You need cysteine or methionine.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on January 16, 2013
at 07:40 PM

Seriously, spamming ain't cool. Twice spamming the same thread, very uncool.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on January 05, 2013
at 05:22 PM

Elemental sulfur and even the sulfur found in cruciferous veg isn't able to be utilized for cystine production, and won't enhance glutathione production.

3ab5e1b9eba22a071f653330b7fc9579

(2262)

on July 19, 2012
at 02:47 PM

garlic, onions, and cruciferous veggies all have sulfur too for people who are looking to up their intake.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 19, 2012
at 12:01 PM

Eh, I've read that before and though the assumptions and suppositions made were shaky. The more I read WAP articles, the more I get disappointed by the poor science in them.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 19, 2012
at 11:48 AM

Cysteine (one of the 3 amino acids in glutathione) is biosynthesized from methionine, which is an essential amino acid, meaning we cannot synthesize it ourselves. We cannot utilize sulfate for glutathione production.

5ccb98f6ae42ce87e206cf3f6a86039f

(11581)

on July 19, 2012
at 09:51 AM

Eat some eggs. Much better than powders and pills.

4e184df9c1ed38f61febc5d6cf031921

(5001)

on July 19, 2012
at 07:41 AM

So would this mean that kefir is a decent source cysteine? Mine often divides into thick kefir and whey...

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12 Answers

7
Eb54f663195dc92f1dab4e0e7ef6b4d0

on July 19, 2012
at 03:33 AM

N Acetyle Cystine, or NAC is a great way to supplement for Glutathione production. I take it twice a day. Other than that, my sister get injections of Glutatione that she swears by, if you can find a doctor that will prescribe it. Some links on NAC:

http://www.biomedcentral.com/content/pdf/1550-2783-2-2-38.pdf

http://www.advance-health.com/nacetylcysteine.html

4
32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 19, 2012
at 11:59 AM

To figure out what to supplement to get enhanced glutathione production, you need to know what glutathione consists of and how it's biosynthesized. Glutathione is a tripeptide of glutamic acid, cysteine and glycine. It's not your typical peptide linkage as the glutamic acid is linked through its side chain. As others have pointed out, cysteine is the limiting point in glutathione production, meaning that's what you'll need to target for supplementation. Glycine and glutamate are common amino-acids, both non-essential.

Cysteine is non-essential, is made from the amino acid methionine, another sulfur containing amino acid. Methionine is essential, meaning we cannot biosynthesize it and it must be obtained via diet.

So any supplementation/feeding strategy to enhance endogenous glutathione production should target increased cysteine and methionine production. Inorganic sulfur (sulfides, sulfites, sulfates, etc...) cannot be used in humans (plants do).

In other words: eat meat.

4
Aaef61c7fe14d78df5995f3025f2ca23

(38)

on July 19, 2012
at 04:59 AM

The three amino acids necessary for glutathione production are cysteine, glutamic acid and glycine...with cysteine being the rate limiting factor for intracellular glutathione synthesis (because it is rare in our food).

A whey protein concentrate is an excellent source of cysteine, and actually contains more than you will find in any other food. I would stick with consuming foods that actually contain the precursers necessary for GSH production before I would look into increasing my sulfur intake.

Here's some more info about whey protein and glutathione if you're interested:)

http://www.wellwisdom.com/pages/Whey-Facts.html#5tharticle

Good luck!

4e184df9c1ed38f61febc5d6cf031921

(5001)

on July 19, 2012
at 07:41 AM

So would this mean that kefir is a decent source cysteine? Mine often divides into thick kefir and whey...

3
6120c989fd5b69f42a0834b69b87955b

(24553)

on July 19, 2012
at 07:16 AM

Sorry to answer your question with a question, I'm too tired to research this right now, but isn't Epsom Salt magnesium sulfate? If the magnesium can be absorbed transdermally, wouldn't the sulphate also be taken up and act as supplemental sulfur?

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 19, 2012
at 11:48 AM

Cysteine (one of the 3 amino acids in glutathione) is biosynthesized from methionine, which is an essential amino acid, meaning we cannot synthesize it ourselves. We cannot utilize sulfate for glutathione production.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:24 PM

Humans do not utilize inorganic sulfates in protein synthesis.

2
4ef079c57d2140bba4dbf4e30240a645

on July 19, 2012
at 05:31 AM

I just happened to see this article today on the Weston A. Price Foundation website.
It may be useful to you.

Sulfur Deficiency
Written by Stephanie Seneff, PhD
July 2 2011

http://www.westonaprice.org/vitamins-and-minerals/sulfur-deficiency

Edited for spelling

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 19, 2012
at 12:01 PM

Eh, I've read that before and though the assumptions and suppositions made were shaky. The more I read WAP articles, the more I get disappointed by the poor science in them.

1
77188106a9c27a22ad47d0ef7318de7a

(922)

on July 19, 2012
at 04:11 AM

MSM Milk Thistle Vitamin C and E (indirectly) Selenium (indirectly) Eggs are also rich in sulfur

3ab5e1b9eba22a071f653330b7fc9579

(2262)

on July 19, 2012
at 02:47 PM

garlic, onions, and cruciferous veggies all have sulfur too for people who are looking to up their intake.

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:23 PM

However, none of those non-amino acid sulfur sources can be used for glutathione synthesis.

0
283ed2c28522c27b90657cbc6024a86c

(0)

on July 11, 2013
at 05:53 PM

I hit this paleohack site googling sulfur and glutathione to try to learn how these to substances work together in the body.

In any case anyone following this thread might be interested in organic sulfur. Which is really just high quality MSM. Seems even if you do eat vegetables that are known to have sulfur in them, the regular run of the mill farming has just about removed sulfur from the food chain/cycle. Sulfur deficiency could be the issue to many health issues. (?)

http://www.naturodoc.com/library/medsmats/msm/sulfur.htm

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:20 PM

Inorganic sulfur/sulfites/sulfates do not get used in protein synthesis. MSM also does not get used in protein synthesis, as far as I've seen. You need cysteine or methionine.

0
D7cc4049bef85d1979efbd853dc07c8e

(4029)

on January 05, 2013
at 04:32 AM

Do Epsom salts (magnesium sulfate) provide sufficient sulphur?

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:21 PM

Humans do not utilize inorganic sulfur for the synthesis of animo acids. Sulfur-containing amino acids must be consumed in amino acid form.

0
9b078c60cba4efbf0e15bca299872161

on July 19, 2012
at 03:39 PM

Protandim, a patented herbal supplement, increases glutathione production by 300%: http://bit.ly/LA7pB0

-1
Fa764249ef0f30075a695590add459e8

on January 16, 2013
at 06:03 PM

The best way to increase your glutathione levels is with Dr Robert Kellers supplement His partners formed RobKeller MD recently and the product is only $39.95 for 180 capsules

I am a direct affiliate with the company.

go to [sales link removed]

and check it out. Your body will thank you!!

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on January 16, 2013
at 07:40 PM

Seriously, spamming ain't cool. Twice spamming the same thread, very uncool.

-1
Fa764249ef0f30075a695590add459e8

on January 16, 2013
at 05:44 PM

The best way to increase your glutathione levels is with Dr Robert Kellers supplement His partners formed RobKeller MD recently and the product is only $39.95 for 180 capsules

I am a direct affiliate with the company.

go to [link removed]

and check it out. Your body will thank you!!

-1
Eaa45c3e06a98bf7d7686d1fc247c69d

on January 05, 2013
at 01:11 AM

we do not get enough sulfur from our diet,in most cases. actually the sulfur you get in powder form does not taste bad at all.i took sulfur when i was young and came to this site wondering if i should resume taking it.i haven'tyet found the answer.i know you get it from the cruciferous vegetables,such as:kale,cabbage,cauliflower,brocoli,radishes and etc.onions and garlic also are sources of sulfur. so,would you recommend supplementing with it or not ?

32f5749fa6cf7adbeb0b0b031ba82b46

(41787)

on July 11, 2013
at 07:22 PM

Not all sulfurous compounds can be used to biosynthesize glutathione, in fact, only the sulfur-containing amino acids can.

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