Honetly, Sean used to be one of the greatest in the business, with the Protandim crap I've lost a lot of respect for him...
If I remember correctly, reading the ingredients for this, I found a number of 'inactive' ingredients listed on this supplement that included magnesium. Magnesium is not inactive! My feelings on most supplements are that they are only going to be useful if they contain something that is lacking in your regular diet. SInce magnesium is lacking in most people's diets, supplementation with magnesium alone would be beneficial to many. I think basically, if you figure out what is lacking in the average diet, and then make a supplement that contains it, then you will find that it has benefits to many. But that does not mean that people already eating a healthy well balanced diet would get the same benefits as those eating SAD. These ingredients are not magic. I would not be surprised if there are many supplements that help many people. There are many many things wrong with most SAD eater diets that could be helped with any number of supplements and/or diet changes. The question in my mind, which I feel has not yet been answered, is if these supplements would give more benefit than just eating whole balanced natural foods or even if they would give any additional benefit on top of already eating whole balanced natural foods. And that kind of research, to my knowledge, has not yet been done.
As an additional aside for your consideration, here is a listing of what is in milk thistle: "The ripe seeds(actually tiny fruits-kenguil seeds) are gathered in late fall to extract the highly medicinal components.The fruit contains 1.5%-3% silymarin, the most active known constituent, along with flavonolignans, tyramine, histamine, essential oils, lipids, alkaloids, saponins, mucilages, flavonoids, and vitamins C, E, and K." So apparently this is a seed, the probably does not want to eaten, and it contains saponins among other things. My feeling is if, for instance, you are low on vit K, C, or E or some other ingredient in milk thistle, you may experience more positives than negs by consuming milk thistle. But if you are already plush with your vitamin intake, you may recieve no benefit at all or there may be ingredients in milk thistle that may even be less than desirable. This is something to consider when looking at supplements.
i haven't tried it, but some of the ingredients are well known to have certain protective benefits, like green tea extract and milk thistle. i'd say theoretically it should work, but no one should expect a freaking miracle. for myself, i supplement with acetyl l-carnitine, green tea extract curcumin and resveratrol before a workout, and it works great (huge difference in stamina and soreness). it all depends on how healthy your mitochondria and metabolism are. if you're perfectly healthy and fit already, the benefits will most likely be minimal at best.
I tried it for a month but honestly didn't feel any differences in my energy, soreness or anything else.
Protandim has changed my life and am a Naturopath that has tried everything for chronic fatigue. I am a new person. People with autoimmune diseases and Alzheimers are greatly benifited from the upregulation of glutathione and SOD along with Nrf2. The sickest will benifit GREATLY by this supplement.