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erythritol and glycation

Answered on August 19, 2014
Created July 10, 2012 at 4:50 PM

Do sugar alcohols (specifically erythritol) cause glycation as sugar does?

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510bdda8988ed0d4b0ec0b738b4edb73

(20898)

on July 10, 2012
at 05:00 PM

Well lets start by looking at the structures of the three molecule

http://en.wikipedia.org/wiki/File:Erythritol_structure.svg

http://en.wikipedia.org/wiki/File:Glucose_chain_structure.svg

http://en.wikipedia.org/wiki/File:D-fructose_CASCC.png

They look almost identical, so I would be they have similar reactivities. The two true sugars have the COOH functional group which is more reactive than a typical OH group, so I would bet that the sugar alcohols are a bet less reactive, but not inert.

Generally though, you body is so efficient at turning things that look like sugar into sugar (it's even pretty good at turning things that don't look like sugar - protein - into sugar through gluconeogensis). I would not be shocked at all to find out that as soon as any sugar alcohol is in the blood your body turns it into a sugar. It's such a small step and your body is good at those kind of reactions. (That's why sugar alcohols are sweet, they're so close to sugar that your body gets confused.)

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