14

votes

Looks like the Paleo diet got a major chest bump in the ACCORD trial. Any comments?

Answered on August 19, 2014
Created March 14, 2011 at 10:02 PM

Look at what just occured about the ACCORD TRIAL. ACCORD showed that type two diabetics lives are cut short by 6 yrs......even showed that the treatment group had higher mortality despite 'improved' lower HgbA1c lab measurements and 'better' blood glucoses with pharmaceuticals! This is h...orrible news for docs and patients. It means that you must never become a diabetic period. Because even with the best medical treatment and best drugs out there you will still have a shortened life. Why? Your mitochondria are not working well and very leaky. The rust faster. And you die sooner!

Here is the most interesting thing however.....While the drugs uses in the ACCORD trial were epic failures for patients and docs.......We have another trial done by a UCSF nephrologist that shows her diet reversed many of the effects quickly (2 Weeks).... Guess what kind of diet it was? PALEOLITHIC!!!! Here is the link.

Frassetto LA, Morris RC, Jr, Sebastian A. Long-term persistence of the ... a Paleolithic-hunter-gatherer-type diet. EJCN 63(8):947-55, 2009

This is the big circle of life in my view and will get physician attn. If you change your diet you can increase your life and reverse type two diabetes. Moreover the type 1.5 diabetics who have had their beta cells fried by the leaky gut and carbohydrate loads are clear now. Paleo dieting improves mitochondrial energy production and life. But it requires you to have a doc who gets it and a patient who buys in to the paleolithic way of eating. What say you Hacks?

B1fcaceba952861d0324bdb291edbbe0

(3159)

on March 24, 2011
at 02:50 AM

Super. Awesome. Wonderful. Fantastic. Yay! Yay! Yay! (composes herself from happy episode and skips away)

B1fcaceba952861d0324bdb291edbbe0

(3159)

on March 24, 2011
at 02:49 AM

Super. Awesome. Wonderful. Fantastic. Yay! Yay! Yay! *composes herself from happy episode and skips away*

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:24 PM

youre interpretation is not mine. This trial showed something more sinister. Those well controlled by good docs DIED alot earlier. COnventional wisdom was that most diabetics can live well and healthy if they get their shit together. This now is a clear message to my profession we had better reverse the metabolic process instead of treating the symptoms.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:22 PM

Low carb needs context though. Every person carb set point to a good metabolism differs.....the lower your body fat the more carbs you can tolerate.....and it will increase your topline performance.....but here is the risk. Carbs cause more ROS out of the mitochindria so if you live this way too long it will effect your telomeres. Oxidation of carbs carries a coefficient of 1.0 while fat and protein metabolism are 0.7 and 0.8. Sounds small but extrapolate this over say 80yrs? The net is huge. If your goal is longevity eat paleo....if your goal is Mike Phelps or Lance sleep with the devil

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:18 PM

you get willpower when you decide to control your own thoughts and not rely on those around you. The mind is an amazing thing. And if you want willpower......use a ton of Zinc Mg and fish oil to change your neurochemistry while you read The Monk who Sold his ferrari. That is how I change a mind who wont think for itself.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:16 PM

And to throw more fire on this trial.....the more ROS the shorter yoru telomeres get........and hence you die quicker. The mechanism of death in ACCORD is pretty damn clear. The goal of the patient and doc must change. Dont treat diabetes....eradicate it asap.

39a1a0bc7855c084ac59df60fdf9c0dd

(1505)

on March 15, 2011
at 11:38 AM

Stephanie - good for your husband! He must be thrilled. I have had a similar experience.

6670b38baf0aae7f4d8ac2463ddc37c0

(3946)

on March 15, 2011
at 01:56 AM

I think that there will be plenty of people who don't have the "will power" to go Paleo to keep the pharms in business. But great news for the growing number of doctors and patients who will give it a chance!

74f5d2ff6567edd456d31dfb9b92af61

(5227)

on March 15, 2011
at 01:45 AM

Why was this down-voted? o.O

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 15, 2011
at 01:39 AM

I am not a fiber nut......I think we need even more fat in the diet to avoid the hard stools honestly. That is why I advocate eating straight coconut oil or having coconut bark made with 50% coconut oil by weight.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 15, 2011
at 01:37 AM

Stabby the key is that we need to keep palmitic acid levels as low as possible. When you eat SFA that means avoiding omega 6's and fructose because of its effects on de nove lipogensis.....and more palmitic acid production. Robb and Matt LaLonde are rock stars.....in my view. Matt is a god send for clinician like me. Guys like him make converting doctors much easier because they have the knowledge to show doctors who think why the lipid hypothesis and carbohydrate issues are problematic biochemically.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 15, 2011
at 01:32 AM

I really think its coming. I spend everyday in my hospital and docs are now coming to me asking me about alot of paleo medical issues. It really has changed a lot recently.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 14, 2011
at 10:25 PM

http://www.nejm.org/doi/full/10.1056/NEJMoa0802743 link to the article

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6 Answers

12
3b5cbb3006f7567b87dd3998ad76ebf8

on March 15, 2011
at 01:14 AM

My husband had insanely positive changes after only 5 weeks strict Paleo when he went in for his regular 3 month diabetes check up. His blood sugar was great, his triglycerides had dropped from almost 400 to 187 and his blood pressure was 120/78 where previously it had been routinely sky high and he had been medicated. He had also dropped 15 lbs. His doctor was in tears after years of watching him struggle to control his blood sugar, lose the same 20 lbs over and over but usually gain more each time and never break his raging sugar addiction. It's many months later and he's doing great! No one has to live with type 2 diabetes but they can't keep eating the way they always did and expect to be free of it nor can they eat any sort of typical American diet.

39a1a0bc7855c084ac59df60fdf9c0dd

(1505)

on March 15, 2011
at 11:38 AM

Stephanie - good for your husband! He must be thrilled. I have had a similar experience.

74f5d2ff6567edd456d31dfb9b92af61

(5227)

on March 15, 2011
at 01:45 AM

Why was this down-voted? o.O

B1fcaceba952861d0324bdb291edbbe0

(3159)

on March 24, 2011
at 02:49 AM

Super. Awesome. Wonderful. Fantastic. Yay! Yay! Yay! *composes herself from happy episode and skips away*

B1fcaceba952861d0324bdb291edbbe0

(3159)

on March 24, 2011
at 02:50 AM

Super. Awesome. Wonderful. Fantastic. Yay! Yay! Yay! (composes herself from happy episode and skips away)

2
Aebee51dc2b93b209980a89fa4a70c1e

(1982)

on March 15, 2011
at 01:07 AM

Dr. K, I hope you're right and that there is eventually a tipping point for paleo diets. Cynical me says that there is little opportunity for Big Pharma to make money off of anything paleo, and in fact that tipping point would end up costing them billions of dollars in revenue, so the chances of seeing the medical community as a whole swing that way are slim at best. I hope I'm wrong.

6670b38baf0aae7f4d8ac2463ddc37c0

(3946)

on March 15, 2011
at 01:56 AM

I think that there will be plenty of people who don't have the "will power" to go Paleo to keep the pharms in business. But great news for the growing number of doctors and patients who will give it a chance!

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 15, 2011
at 01:32 AM

I really think its coming. I spend everyday in my hospital and docs are now coming to me asking me about alot of paleo medical issues. It really has changed a lot recently.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:18 PM

you get willpower when you decide to control your own thoughts and not rely on those around you. The mind is an amazing thing. And if you want willpower......use a ton of Zinc Mg and fish oil to change your neurochemistry while you read The Monk who Sold his ferrari. That is how I change a mind who wont think for itself.

1
93b2e3c143c962cf8c92e6316a483ddf

(150)

on March 15, 2011
at 02:32 PM

Basically, this trial showed only that poorly-controlled, long-time diabetics did not respond well to intensive drug therapy. It has nothing to say about achieving low A1c levels by diet. Another recent study showed that for every 1% increase above an A1c of 5.4%, there is a 19% greater risk of myocardial infarction.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:24 PM

youre interpretation is not mine. This trial showed something more sinister. Those well controlled by good docs DIED alot earlier. COnventional wisdom was that most diabetics can live well and healthy if they get their shit together. This now is a clear message to my profession we had better reverse the metabolic process instead of treating the symptoms.

1
Fac1af832cc3c6a20059c41411fd0f6b

(1548)

on March 15, 2011
at 07:48 AM

THis is good news. And coupled with the news that insulin levels are linked to myopia and that ADHD can be treated through diet it seems readily apparent that a whole host of what we thought were unrelated maladies are caused not by bad breeding, but by bad diet. I cannot tell you what sort of relief that is for me.

0
8f4ff12a53a98f3b5814cfe242de0daa

(1075)

on March 15, 2011
at 03:28 AM

Low carb anything is actually becoming conventional wisdom for diabetes treatment now.

My insurance company even recommends a low carb diet that would be paleo if you did not specify the "no seed oils" portion.... So I would say the medical establishment is not exactly sticking there heads in the ground.

That said, in these sort of trials it is always a specifically high fat low carb sort of paleo, and Atkins usually does a comparable job. Here is an article from 2006 advocating the change in CW http://diabetes.webmd.com/news/20060616/do-low-carb-diets-help-diabetes .

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 20, 2011
at 02:22 PM

Low carb needs context though. Every person carb set point to a good metabolism differs.....the lower your body fat the more carbs you can tolerate.....and it will increase your topline performance.....but here is the risk. Carbs cause more ROS out of the mitochindria so if you live this way too long it will effect your telomeres. Oxidation of carbs carries a coefficient of 1.0 while fat and protein metabolism are 0.7 and 0.8. Sounds small but extrapolate this over say 80yrs? The net is huge. If your goal is longevity eat paleo....if your goal is Mike Phelps or Lance sleep with the devil

0
Be1dbd31e4a3fccd4394494aa5db256d

(17969)

on March 15, 2011
at 01:19 AM

Ah yeah I'm familiar with this study (or at least the abstract). I have been saying this for a while - the causes of type 2 diabetes are basically eating the SAD! No doubt it can be reversed so long as they have at least some life left in them.

Reverse tissue HUFA. Low omega 6 diet. High omega 3s at least for a month. Lots of saturated fat for adiponectin Lots of protein to dejunk the liver and rebuild health Repair gut with smart proteins, coconut and grain avoidance Get enough nutrients FFS Exercise if you can Get sleep working on your side. I'm still a fiber-nut. It is seriously good stuff to get enough fiber, particular inulin.

Over on MDA we get big fat people with triglycerides at like 300 and turn them healthy in 6 months. Robb Wolf sees the same thing.

Ah but without grains how will they poop? Hrmf.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 15, 2011
at 01:39 AM

I am not a fiber nut......I think we need even more fat in the diet to avoid the hard stools honestly. That is why I advocate eating straight coconut oil or having coconut bark made with 50% coconut oil by weight.

Ed71ab1c75c6a9bd217a599db0a3e117

(25477)

on March 15, 2011
at 01:37 AM

Stabby the key is that we need to keep palmitic acid levels as low as possible. When you eat SFA that means avoiding omega 6's and fructose because of its effects on de nove lipogensis.....and more palmitic acid production. Robb and Matt LaLonde are rock stars.....in my view. Matt is a god send for clinician like me. Guys like him make converting doctors much easier because they have the knowledge to show doctors who think why the lipid hypothesis and carbohydrate issues are problematic biochemically.

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