How does a paleo-type diet affect health outcomes on those with cystic fibrosis? Any heterozygotes (carriers) with anything to share?
I am a carrier. I respond well to a nearly zero carb (and fiber), high fat diet. Any significant quantities of starch cause indigestion. Most sources of fiber as well, with the exception of those that are unaccompanied by starch, such as lettuce.
This question is an attempt to get some data on a subject for which I can find no discussion anywhere. :)
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Heterozygote carrier. I can only speculate about its effects. Reading up on CF, excess production of mucus appears to be a major effect. When I was little, I had frequent ear infections. I assume that excess production of mucus block drainage of the ear and caused infection. In adulthood, pre-paleo I frequently was constipated. I assume mucus production played a role.
Post-paleo, I haven't had problems with ear infections. Of course, if I eat meat only, I'll feel constipated.
The CF gene affects chloride transport. Personally, I'm a little obsessed with getting salt intake right. Last night, I eat a grapefruit and three plums before going out. In my car, I realized that I felt salt deficient and looked for the first restaurant to stop and get some salt. I had been keeping a container of salt in the car for situations such as this, but accidentally bought it into the house. Fruit is high in potassium and salt is needed to balance it out. Usually, I am fine with salt balance because I add it in when I cook. But sometimes I just forget and need it. Before I figured out I needed salt, I felt thirsty and just drank water, pissed it out and still felt thirsty.