What is the easiest way to figure out the minimal effective dose of supplementation and dietary change to adjust for the following genetics? It seems that I have minor defects, but nothing serious. All other things being equal, I would love to... (more)
We are our genes, but our genes are not our fate. As a paleo community we tend to concern ourselves greatly with our natural heritage, our predispositions and our gene expressions. We are very interested in bringing out the best of what we are and... (more)
Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)
For those who got APOE 4/4 result on genetic testing (http://snpedia.com/index.php/APOE). What have you learned during your experimentation with diet, supplementation and with overall lifestyle changes?
Did you learn something that lead to a significant change in your daily routine? Do you think your health will be even better now that you have this new information? Do you trust the results? Do you think the science is too young to be... (more)
Is this done through one's doctor, or is there a more accurate genetic testing method that one's doctor might not be aware of? Is there a lab out there that studies this particular genetic condition that also offers testing to the public? I am... (more)
Since a good part of the paleo rationale is based on the idea that we are not genetically adapted to eat a certain way, it seems very relevant and quite interesting to look at this example of how quickly such a genetic mutation/adaptation can... (more)
You know those guys you see who are naturally muscular and barely lifts weights? How do you explain that? I kind of envy them. I have sucky genetics and have to work my ass off for every inch of muscle i gain. Thoughts?
I was talking with some relatives who have stomach problems and one thing I noticed is that a lot of them are on NSAIDs- ibuprofen and aspirin, for example. Over the years I have been on and off the paleo diet, but never gotten back to the point I... (more)
I'll start with my question: Do you agree with Melissa McEwen's critique of Jack Kruse's (mis)use of evolutionary biology? I should note that I am a fan of both McEwen and Kruse. McEwen's blog post is... (more)
You have no idea how hard that post was to write. I mean, it's so hard to read Dr. Kruse's writing and find consistant threads in it. He has references on the bottom of some post, but mostly they do not correspond to things in his posts that I... (more)
Hi! Because of constipation, which is now better, my G.I specialist got me to take a blood test to see if I have celiac or not. The results were that I'm a carrier for Celiac disease but it came back negative. My aunt didnt develop properly... (more)
You probably are not looking for grounds upon which to sue 23andme, but... The word "actionable" means "affording grounds for legal action" and "violating principles of justice." I get that you mean something closer to: "Based on one's genome,... (more)
Hi! Who here legitimately forgets to eat? Or has less interest in food than people in general? I've had a brief history of overeating, but that was due to addictive foods on the S.A.D that I leeched onto after being through a long period of... (more)
I recently found out (from 23andme) that I am heterogeneous (one copy of the "bad" gene) for the MTHFR C677T polymorphism. This means that my body has reduced ability to convert folate into the active form of folate (5-methyltetrahydrafolate).... (more)
Loaded question I know, but this is a really interesting piece on DNA being changed by the foods we eat. We Incorporate Genetic Information From the Food We Eat, New Study Finds
Pyroluria-- Is it real? Is it permanent? Those that pay attention to it regard it as genetic, requiring permanent B6 supplementation. Nora Gedgaudas in "Primal Mind Primal Body" has a whole appendix on it and seems to share this view. Any... (more)
Just got my 23andme data back -- would love to know what is the best way to get the most actionable data out of it. What should I look at that will let me make a change in my diet, lifestyle, fitness today? Anything? (more)
Chris and I were having a conversation about how some people do really awesome on pretty low carb and some people feel sick. I started getting curious about whether this might have something to do with "neanderthal ancestry." If you have DNA data... (more)
So I'm 24, and have been hardcore paleo/primal for 1 yr. I've always been athletic, but now am leaner, stronger, faster, etc than ever now. However, at times I still have trouble with the paleo lifestyle - trouble that goes past just getting,... (more)
Someone mentioned this in Patrick's earlier thread, but let me make it abundantly clear-- 23andme.com is having a sale right now. They have a sale about once every couple years. Their ancestory/health DNA sequencing service is down from $499... (more)
Was wondering what the survival advantage could have been and came across this paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917125/?tool=pubmed (full free text) From the abstract: "All humans are double knockouts. Humans lack the... (more)
Evolution didn't just stop with the invention of agriculture. Genetics have changed and there have been some genetic changes in response to agrarian foods. These genetic changes generally only affect a certain percentage of the population, often... (more)
Loren Cordain argues (without a citation) that the human genome has chagned only .02 percent in 40,0000 years. But other sources say that because of population growth, human genetics has changed much more rapidly in the last 5,000 years than the... (more)
Fun article about fermented foods in the Arctic circle
Who wants to do Whole30 with me?
Paleo and Body Type Theory?