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Is cancer a metabolic disease?

Commented on April 26, 2014
Created April 24, 2014 at 9:28 PM

Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

Is cancer a body's failure to attain global metabolic fitness?

-http://www.medscape.com/viewarticle/719423

-http://www.singlecausesinglecure.org/metabolic-theory-of-cancer/

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on April 26, 2014
at 01:33 PM

This is a good video, ty for sharing!

Medium avatar

(626)

on April 25, 2014
at 06:36 PM

This is one reason I've been looking into protein fasting. It makes sense that H/G peoples would spend a day here and there with no meat and little protein/mostly fruit. Heck, they might go a week without a good kill and then engorge for a couple days before the corpse rots.

32f5749fa6cf7adbeb0b0b031ba82b46

(41767)

on April 25, 2014
at 05:48 PM

Hunter-gatherers don't run out of food. Women would gather and men would hunt. Gathered foods were dependable, hunted foods were not. It's a way to romanticize fasting.

De1095b2ba29c1035f00428cbfe3cc7c

(787)

on April 25, 2014
at 04:33 PM

Abstaining from food for a period of time, it could be skipping the odd meal or not eating food for many days, both could be called 'paleo' as our ancestors wouldn't have eaten 3 meals per day everyday for their whole lives, and would've at time run out of food possibly for days on end

Medium avatar

on April 25, 2014
at 04:06 PM

I'm relatively new to Paleo. What sort of fasting would help this?

3ce6a0d24be025e2f2af534545bdd1d7

(26217)

on April 25, 2014
at 12:28 PM

ask Lance Armstrong

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4 Answers

0
7a777966a2b7f30251c358b6fe35936f

on April 26, 2014
at 11:38 AM

Latest evidences shows that cancer should also be considered as a metabolic disease. Cancer is associated with meatbolic changes. The metabolic profile of tumor cells has been suggested to reflect the rapid proliferative rate.

0
Be803dcde63e3cf5e21cc121097b8158

on April 26, 2014
at 08:24 AM

Since we're on a Paleo forum, this lecture by Dr. Eugene Fine immediately came to mind: http://youtu.be/04A5U6IlHqk

Cb9a270955e2c277a02c4a4b5dad10b5

(10979)

on April 26, 2014
at 01:33 PM

This is a good video, ty for sharing!

0
F291857fa12a0291688ea994343156dc

(720)

on April 26, 2014
at 04:25 AM

Here's a post on the metabolism of cancer cells

Peter Attia

http://eatingacademy.com/nutrition/war-cancer

0
96440612cf0fcf366bf5ad8f776fca84

(19142)

on April 25, 2014
at 10:27 AM

One of the features is that the mitochondria in cancerous cells is broken and can only process glucose (and possibly fructose), they cannot do beta oxidation - (the other, more critical, is that they no longer respond to apoptosis.) So in that sense, yes.

Note that there are some cancers where this isn't true, and they can do beta oxidation, so it won't work in every case. But as a general preventative rule, it's a good idea to do some fasting once in a while so as to kill off any cells with broken mitochondria and invoke apoptosis in marginal ones.

Medium avatar

on April 25, 2014
at 04:06 PM

I'm relatively new to Paleo. What sort of fasting would help this?

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