Collected 10/5/12 - Shiel Medical Lab - day 14 (before Testosterone injection) - I'm on TRT - get an injection every 2 weeks
HA1C - 5.6 Fasting Glucose - 100mg/dL Ref Range 65-99 mg/dL Estimated Average Glucose - 114.5 mg/dL
LDL-P 1430 nmol/L Small LDL-P 132 nmol/L
HDL-C 69mg/dL Triglycerides 31 mg/dL Trig/HDH ratio - .45
LDL-C (Calculated) 199 mg/dL LDL-C (Iranian Formula) 146 mg/dL
TC - 274 mg/dL
Estradiol, LC/MS/MS - 4 pg/mL S/B <= 29 pg/mL Enhanced Estradiol - 22.7 pg/mL Ref Range <39.8 pg/mL SHBG - 39 nmol/L Ref Range 11 - 80 nmol/L
Thyroid Panel Thyroxine (T4) - 10.9 ug/dL Ref Range 4.5 - 10.9 ug/dL T3-Uptake - 34.0% Ref Range 22.5 - 37% TSH - 3rd Generation Ultra - 1.47 uIU/mL Ref Range 0.40 - 4.50 uIU/mL Reverse T3, LC/MS/MS - 34ng/dL Ref Range 9 - 28 ng/dL T3, Total 81 ng/dL - Ref Range 60 - 181 ng/dL T4, Free 1.43 ng/d/L - Ref Range 0.80 - 1.80 ng/dL
Vitamin D (25 hydroxy) - 74 ng/dL Ref Range 30 - 100 ng/dL Cardiac Homocysteine - 10.0 umol/L Ref Range <11.4 umol/L PSA - 0.42 ng/d/L Ref Range <4.00 ng/dL
Quest Diagnostics - collected 10/8/12 (3 days AFTER the testosterone shot) Just to show how different labs get different results
Berkley Heart Labs Test
LDL PAttern Size A (Large) Triglycerides - 41 mg/dL HDL-C 76 mg/dL Trig/HDL ratio .54
Apolipoprotein B - 104 mg/dL Ref Range <115 mg/dL
One thing that does not make sense Oxidized LDL - 62 U/L Ref Range 9-44 U/L
Low Risk <45 Moderate Risk 45-59 High Risk 60-79 Very High Risk >79
HOWEVER - Shiel didn't run their HDL test as part of the Triple Marker test so I didn't get the Oxidized LDL/HDL ratio so I'll wait 6 months and run it again.
Total LDL-C 158 mg/dL (Berkeley Heart Lab LP Plus3 Test) HDL-C 79 mg/dL Triglycerides 41 mg/dL
Per the Iranian Formula the LDL - 118 mg/dL - MUCH BETTER
HOWEVER - the LDL subclasses are what's interesting
LDL IVb - 1.8% Ref Range 1.7% - 9.8% LDL IVb goal - <= 5% SO - This represents very low cardivascular risk
LDL IIIa + IIIb - 17.9 mg/dL Ref Range 12.0 - 32.1 mg/dL Again - low risk
LDL IVb - 1.0 mg/dL Ref Range 1.5 - 11.2 mg/dL Again - VERY LOW risk
So - total LDL-C doesn't mean much - BUT - they base giving statins on that number
asked byAgingHippie (614)
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on June 02, 2013
at 06:40 AM
Did you ever find a cause for your high ox-LDL?
I know of one genetic haplotype that is associated with high oxidized-LDL, among other problems. There may be others.
Do you have genetic data (from 23andme, FTDNA, etc.)? The gs224 haplotype is a group of three mutations on the GCH1 gene that appear to reduce BH4 levels, and cause high oxidized LDL; if you run SNPedia's Promethease program, it will tell you if you have this particular set of mutations.
About 2% of the population carries gs224.
Here's a study with the gs224 GCH1 haplotype correlated with ox-LDL: http://circ.ahajournals.org/cgi/content/meeting_abstract/118/18_MeetingAbstracts/S_552-d "... The X haplotype was also associated with higher plasma ox-LDL (51.0??2.2 in XX+XO vs 44.2??1.4 U/L in OO p<0.05) and lower BH4:total biopterins ratio (43.1??3.2 in XX+XO vs 51.7??2.1% in OO, p<0.05)."
Yahoo group for the gs224 haplotype: http://health.groups.yahoo.com/group/GCH1discussions
on October 19, 2012
at 11:23 PM
Your LDL-P number is probably in the 70th percentile and is a cause for some concern. If you weren't eating a lower-carb/paleo diet, I'd say get on one. However, that measurement is discordant with your apoB number (good), trigs and HDL numbers (amazingly good), so I don't know what to make of it. I'm not an expert on the effects of testosterone injections, and can't say whether that should or shouldn't be affecting your LDL-P results.
LDL particle size and plasma concentration are, according to Dr. Tom Dayspring, irrelevant.
TC is slightly above the sweet spot (220-240).
Your thyroid panel is missing an important measure: Free T3. It's only the free T3 that's available to do it's job. But your high RT3 suggests that your FT3 might be low.