Extract from a paper: An intuitive explanation for why high cholesterol at an early age might be correlated with Alzheimer's risk has to do with apoE-4. People with that allele are known to have high cholesterol early in life , and I... (more)
EDIT: Just found an article that seems to substantiate my hunch, below: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2002507/ My original posting: There is probably no correlation because such a wide range of factors--such as genes and... (more)
Dear all! What do you think about creating the ultimate hacking thread for Apo-??4/??4 gene mutations to discuss practical real-life implications. What worked and what did not for cholesterol numbers and overall well-being in terms of lifestyle,... (more)
On Jimmy Moore's Ask the Low Carb experts, he had Dr. Steven Gundry on and he said something I've never heard or come across before. He said people with the APO-E4 gene, which is 20% of the population, that a diet high in animal fat is damaging... (more)
I'll try and keep this concise. I'm currently 6ft and 205 lbs. Late last year I was diagnosed with NAFLD (mild/moderate) as the result of the Dr finding elevated ALT levels in blood work. I've been dealing with some chronic light-headedness... (more)
I can't seem to lower my cholesterol & triglycerides (~290) after a year of Paleo. And I still have a fatty liver. I'm starting to think that I'm an APoE 4/4 carrier, where a high-fat diet just doesn't work as well as in most others (5% of the... (more)
The APOE 4/4 allele is considered a "paleo" version of the APOE gene (1). It's hypothesized that carriers of this allele may be more adapted to a paleo diet, intermittent caloric restriction and exercise than non-carriers. In fact avoidance of a... (more)
The APOe gene encodes for a protein associated with triglyceride metabolism but its also implicated in Alzheimer's disease. It has been suggested that a variant of the APOe gene - APOe4 - may confer a survival advantage at times of famine (1) -... (more)
2 Months ago, I posted a question I'm still hacking on about finding optimum lipid profile for heart/brain health in APOE4 here... http://paleohacks.com/questions/80505/potential-hacks-resolve-heart-brain-dilemma-for-apoe4#axzz1klJhxOz9 I've been... (more)
First of all, I'm assuming the hypothesis that ApoE4 carriers (one or two alleles) face the problem of high LDL Cholesterol and TC, probably due to a diet high in saturated fat. If that holds true, and according to various blogs (Dr. Davis, Paul... (more)
Looking for some suggestions on hacks to resolve what appears to be a heart/brain dilemma associated with apoE4 allele? Experimenting on myself as safer/quick guinea pig for my father. He has been lifelong sufferer of minor Essential Tremor,... (more)
I found my lipid profile from a blood sample taken just before going strict paleo. Here it is compared with my present numbers from 2 days ago (2-1/2 year span): TC = 188 / 372 TG = 89 / 74 HDL = 50 / 73 LDL = 120 / 284 Obviously there is... (more)
I just came across this interesting study and I'm not sure what to make of it. In a randomized controlled trial, participants were fed either white bread or whole grain sourdough style wheat bread for 6-weeks (the whole wheat contained some other... (more)
Fun article about fermented foods in the Arctic circle
Who wants to do Whole30 with me?
Paleo and Body Type Theory?